BCD

The exterior face of the truncated cone of BCD is hydrophilic this facilitates solubilisation of the complex in the GI fluids by shielding the lipophilic guest molecule from the polar forces of water. Once in the gut lumen, the lipophilic guest molecule dissociates at the lipid membrane of the superficial lining cells. These lipids at the cell interface have greater affinity for the lipophilic guest molecule than does BCD. The librated guest molecule passes into the lining intercellular matrix, lymphatics, and capillaries.