IMPROVEMENT IN TMAX

The Tmax of a drug reflects how fast it can reach maximum concentrations in plasma. The faster a drug reaches peak plasma concentration, the faster will the drug show maximum therapeutic action. This is particularly important for drugs that relieve pain.
In crossover study of 12 healthy volunteers comparing the Tmax of valdecoxib in BCD vs valdecoxib alone, valdecoxib in BCD achieved maximum plasma concentration earlier than valdecoxib alone. The investigators found that valdecoxib alone reached peak plasma levels in 2.45 hours shown in figure